Hydrogen chloride-ethyl acetate → HCID 66892842, compound

HRID 1513590Notes

Reaction equation

HRID 1513590 reaction equation
[CH3:1][O:2][C:3]1[C:7]2[C:8](=[O:25])[N:9]([CH2:16][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]=2[S:5][C:4]=1[C:26]([NH:28][CH2:29][CH2:30][NH:31][CH:32]([CH3:34])[CH3:33])=[O:27].C(OC(=O)C)C.[ClH:41]>C(OCC)(=O)C>[ClH:41].[CH3:1][O:2][C:3]1[C:7]2[C:8](=[O:25])[N:9]([CH2:16][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]=2[S:5][C:4]=1[C:26]([NH:28][CH2:29][CH2:30][NH:31][CH:32]([CH3:34])[CH3:33])=[O:27]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57859971HCID 57859971, compound

Product 1

HCID 66892842HCID 66892842, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of the compound of Example 97 (150 mg, 0.30 mmol) in ethyl acetate (10 mL) was added 4N hydrogen chloride ethyl acetate solution (0.1 mL), and the resulting precipitate was collected by filtration, washed with ethyl acetate, and dried under reduced pressure to give the title compound (107 mg, 69%) as a white powder.

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with ethyl acetate
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-94b5ef8258804f34914755f21c5d22e5
Source dataset
uspto-grants-2012_07
Patent number
US08217176B2

Reaction notes

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