反应详情

A mixture of 8-[1-(chloromethyl)ethenyl]-3,7-difluoro-2-(methyloxy)-1,5-naphthyridine (320 mg, 1.18 mmol) and sodium iodide (885 mg) in acetonitrile (20 ml) was heated to reflux for 20 hours. The cooled mixture was evaporated then diluted with water and extracted with dichloromethane. The organic extracts were dried over magnesium sulphate and evaporated. The residue was chromatographed on silica eluting with a gradient of 0-100% ethyl acetate in hexane affording product (168 mg, 65%).

1. temperaturewas heated
2. temperatureto reflux for 20 hours
3. customThe cooled mixture was evaporated
4. additionthen diluted with water
5. extractionextracted with dichloromethane
6. dry with materialThe organic extracts were dried over magnesium sulphate
7. customevaporated
8. customThe residue was chromatographed on silica eluting with a gradient of 0-100% ethyl acetate in hexane affording product (168 mg, 65%)