反应详情

2-Amino-6-bromopyridine 10 g (58 mmol), phenylboronic acid 8.5 g (70 mmol) and tetrakis(triphenylphosphine)palladium 1.3 g (1.2 mmol) were dissolved in 60 mL of 1,2-dimethoxyethane. A 2.0M sodium carbonate aqueous solution 30 mL was added thereto, and the solution was refluxed for 8 hours under argon atmosphere by heating. After finishing the reaction, the aqueous layer was removed. The organic layer was dried on anhydrous magnesium sulfate, and the solvent was removed by distillation under reduced pressure. The residue was refined by silica gel chromatography to obtain 6.9 g (yield: 70%) of 2-amino-6-phenylpyridine.

1. temperaturethe solution was refluxed for 8 hours under argon atmosphere
2. temperatureby heating
3. customthe reaction
4. customthe aqueous layer was removed
5. dry with materialThe organic layer was dried on anhydrous magnesium sulfate
6. customthe solvent was removed by distillation under reduced pressure