HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1513862Generated: November 2, 2026
Hydrochloric Acid → 6-Benzyloxy-2-bromo-naphthalen-1-ol
https://huagongshe.com/reaction/1513862
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 6-(Benzyloxy)-2,2-dibromo-1,2,3,4-tetrahydronaphthalen-1-one | HCID 67004794 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Benzyloxy-2-bromo-naphthalen-1-ol | HCID 67005158 | 92.3% |
Reaction Steps
Add 1M sodium methoxide (215 mL, 0.99 mol) into a solution of 6-benzyloxy-2,2-dibromo-3,4-dihydro-2H-naphthalen-1-one (205 g, 0.5 mol) in methanol (1.3 L). Heat the suspension to dissolution. Cool the reaction mixture to 0° C. and add 1N HCl (540 mL). Add H2O (3 L) and cool to 3° C. to obtain a solid. Filter and dry the solid to obtain 152 g (92%) of 6-benzyloxy-2-bromo-naphthalen-1-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08217032B2 |
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| Source dataset | uspto-grants-2012_07 |
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| ORD ID | ord-794f2739d0b64b4282f2d9eaf80dae75 |
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| Source note | uspto-grants-2012_07 |
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