反应详情

温度

0 °C

Add 1M sodium methoxide (215 mL, 0.99 mol) into a solution of 6-benzyloxy-2,2-dibromo-3,4-dihydro-2H-naphthalen-1-one (205 g, 0.5 mol) in methanol (1.3 L). Heat the suspension to dissolution. Cool the reaction mixture to 0° C. and add 1N HCl (540 mL). Add H2O (3 L) and cool to 3° C. to obtain a solid. Filter and dry the solid to obtain 152 g (92%) of 6-benzyloxy-2-bromo-naphthalen-1-ol.

1. temperatureHeat the suspension
2. dissolutionto dissolution
3. customto obtain a solid
4. filtrationFilter
5. customdry the solid