HRID1513924
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 100 °C
PROCEDURE
实验过程
Dissolve trifluoromethanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-naphthalen-2-yl ester (752 mg, 1.4 mmol), 2,4,6-trifluorophenylboronic acid (493 mg, 2.8 mmol), potassium phosphate (1.8 g, 8.4 mmol)) and tetrakis(triphenylphosphine)palladium (324 mg, 0.3 mmol) in dry dimethylformamide (DMF, 25 mL) and heat at 100° C. for 20 minutes. Purify reaction on an SCX column to yield 674 mg (93%) of the title compound. Mass spectrum (ion spray): m/z=520.2 (M+H).
WORKUP
后处理
- customPurify
- customreaction on an SCX column