反应详情

温度

50 °C

Dissolve 5-{hydroxy-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methyl}-6-(2,4,6-trifluoro-phenyl)-naphthalen-2-ol hydrochloride (730 mg, 1.4 mmol) and potassium tert-butoxide (5.36 mg, 4.8 mmol) in dry DMF (25 mL) and heat at 50° C. for 10 minutes. Cool reaction and pour onto ice/ethyl acetate. Separate organic layer and wash with 10% aqueous lithium chloride. Dry, filter, and concentrate in vacuo. Purify by silica gel chromatography using a 1-6% gradient of methanol in dichloromethane to yield 532 mg (76%) of the title compound.

1. temperatureCool
2. customreaction
3. additionpour onto ice/ethyl acetate
4. washSeparate organic layer and wash with 10% aqueous lithium chloride
5. customDry
6. filtrationfilter
7. concentrationconcentrate in vacuo
8. customPurify by silica gel chromatography