反应详情

Dissolve 8,10-difluoro-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-5H-6-oxa-chrysen-2-ol (532 mg, 1.1 mmol) in dichloromethane (10 mL) and add 2M HCl (1.1 mL, 2.2 mmol) and stir for 10 minutes. Concentrate in vacuo to yield 536 mg (100%) of the title compound. Mass spectrum (ion spray): m/z=488 (M+H−HCl). Separate the racemate into its constituent enantiomers by chiral chromatography. Conditions: Column: Chiralcel OD 4.6×150 mm; Eluent: 0.2% DMEA, 5% MeOH, 10% 3A Alcohol in Heptane.

1. concentrationConcentrate in vacuo