反应详情

Dissolve [2-(4-fluoro-2-methylsulfanyl-phenyl)-6-methoxy-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone (1.2 g, 2.2 mmol) in dry THF (20 mL). Add lithium aluminum hydride (1M in THF, 2.3 mL, 2.3 mmol) dropwise. After 10 minutes slowly pour the black solution into saturated aqueous ammonium chloride and extract with methylene chloride twice. Dry the combined organic layers with sodium sulfate, filter and concentrate to yield a 2:1 mixture of rotational diastereomers. Dissolve the crude foam in dry THF (15 mL). Add diisopropylethylamine (2.5 mL, 14.4 mmol) and methanesulfonyl chloride (0.45 mL, 5.8 mmol) and heat to reflux under nitrogen. Add more methanesulfonyl chloride (0.45 mL, 5.8 mmol) after 2 hours to drive the reaction to completion. Pour the reaction into saturated aqueous sodium bicarbonate and extract twice with methylene chloride. Dry the combined organic layers with sodium sulfate, filter and concentrate. Purify the residue on silica gel (0% to 3% methanol in methylene chloride) to yield 440 mg (44%) of the title compound: mass spectrum (ion spray) m/z=500.3 (M+H).

1. extractionextract with methylene chloride twice
2. dry with materialDry the combined organic layers with sodium sulfate
3. filtrationfilter
4. concentrationconcentrate
5. customto yield
6. additiona 2:1 mixture of rotational diastereomers
7. temperatureto reflux under nitrogen
8. customthe reaction to completion
9. additionPour
10. extractionextract twice with methylene chloride
11. dry with materialDry the combined organic layers with sodium sulfate
12. filtrationfilter
13. concentrationconcentrate
14. customPurify the residue on silica gel (0% to 3% methanol in methylene chloride)