Hydrogen Bromide → HCID 67140438, compound

HRID 1514040Notes

Reaction equation

HRID 1514040 reaction equation
C([O:3][C:4](=[O:36])[C:5]([NH:32]C(=O)C)([CH2:11][C:12]1[CH:13]=[CH:14][C:15]2[N:16](C(OC(C)(C)C)=O)[C:17]3[C:22]([C:23]=2[CH:24]=1)=[CH:21][CH:20]=[CH:19][CH:18]=3)C(OCC)=O)C.Br>>[NH2:32][CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]2[NH:16][C:17]3[C:22]([C:23]=2[CH:24]=1)=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:4]([OH:36])=[O:3]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 59814445HCID 59814445, compound

Product 1

HCID 67140438HCID 67140438, compound

Procedure

2-Acetylamino-2-(9-tert-butoxycarbonyl-9H-carbazol-3-ylmethyl)-malonic acid diethyl ester (200 mg, 0.4 mmol) was combined with hydrogen bromide (4 mL of a 24% aqueous solution) and refluxed for about 12 h. The cooled reaction mixture was evaporated under reduced pressure and dried under high vacuum to afford the amino acid as the hydrogen bromide salt. ES-MS (M+H)+ 255.0 (calc. 254.1).

Workup

  1. temperaturerefluxed for about 12 h
  2. customThe cooled reaction mixture
  3. customwas evaporated under reduced pressure
  4. customdried under high vacuum

Sources & evidence

ORD record
ord-a29668d3b20a44fea6ae942c3678b436
Source dataset
uspto-grants-2012_07
Patent number
US08222215B2

Reaction notes

Loading…