HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenyl chloroformate → 3-(Trifluoromethyl)phenyl 4-(prop-2-ynyl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenyl chloroformate | HCID 5057425 | — |
| Reactant | Tert-butyl 4-(prop-2-yn-1-yl)piperidine-1-carboxylate | HCID 18187546 | — |
| Product | 3-(Trifluoromethyl)phenyl 4-(prop-2-ynyl)piperidine-1-carboxylate | HCID 57838900 | — |
Reaction Steps
3-(trifluoromethyl)phenyl chloroformate (5.0 g, 29.3 mmol) was added to a solution of tert-butyl 4-(prop-2-ynyl)piperidine-1-carboxylate (1.50 g, 6.72 mmol) according to general procedure 1. Yield=1.1031 g, 64%. m/z MH+=302.02. HPLC rt=10.8 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222228B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-3af6dea1e8294ec0af833a80aab5b541 |
| Source note | uspto-grants-2012_07 |