Acetic Anhydride → HCID 59138690, compound

HRID 1514078Notes

Reaction equation

HRID 1514078 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[OH:9])=[CH:4][CH:3]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>ClCCl.CN(C1C=CN=CC=1)C>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]([O:9][C:16](=[O:18])[CH3:17])[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 7918Acetic AnhydrideHCID 20145726HCID 20145726, compound

Product 1

HCID 59138690HCID 59138690, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of (6-chloro-pyridin-3-yl)-phenyl-methanol (2 g, 9.10 mmol) in dichloromethane (25 ml) were added acetic anhydride (3.5 ml, 36.4 mmol) and DMAP (1.10 g, 9.10 mmol). The reaction mixture was stirred for 16 hours, and then was washed with water, dried and concentrated to give acetic acid (6-chloro-pyridin-3-yl)-phenyl-methyl ester as a viscous liquid. LC/MS (m/z) 262.12 [(M+H)+]; HPLC Rt: 3.011 min.

Workup

  1. washwas washed with water
  2. customdried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-f51622530c294c4a8392986f8dec0c56
Source dataset
uspto-grants-2012_07
Patent number
US08222247B2

Reaction notes

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