Hydrazine hydrate (1:1) → 3-[4-(2-Methoxyphenyl)piperazino]propanohydrazide

HRID 1514153Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1514153
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C:17]([O:19]CC)=O)[CH2:11][CH2:10]1.O.[NH2:23][NH2:24]>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C:17]([NH:23][NH2:24])=[O:19])[CH2:11][CH2:10]1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 12234156Ethyl 3-[4-(2-methoxyphenyl)piperazino]propanoate

Produkt 1

HCID 8724333-[4-(2-Methoxyphenyl)piperazino]propanohydrazideAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of ethyl 3-[4-(2-methoxyphenyl)piperazino]propanoate D1 (8.30 g, 28.38 mmol) and hydrazine monohydrate (8.52 g, 8.3 mL, 170.03 mmol) in ethanol (80 mL) was refluxed for 18 hrs. The solvent was evaporated under reduced pressure, the resulting solid was slurred in 50% acetone in hexane, filtered and dried to afford 6.80 g (87%) 3-[4-(2-methoxyphenyl)piperazino]propanohydrazide D2 as a white solid.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. filtrationfiltered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ba3dec44e37249a9995bca6b109ddbb5
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08222254B2

Notizen zur Reaktion

Wird geladen…