反应详情

A suspension of N-(cyclohexylmethyl)-2-{3-[4-(3-nitrophenyl)piperazin-1-yl]propanoyl}hydrazine carboxamide D8 (0.70 g, 1.62 mmol) in 2M NaOH aqueous solution (10 mL) was heated at reflux for 5 hrs, then cooled to room temperature and brought to pH 8 by the drop-wise addition of HCl 28%. The resulting precipitate was filtered, washed with water and diethyl ether to afford 0.60 g (89%) 4-(cyclohexylmethyl)-5-{2-[4-(3-nitrophenyl)piperazin-1-yl]ethyl}-2,4-dihydro-3H-1,2,4-triazol-3-one D9 as a yellow solid.

1. temperaturewas heated
2. temperatureat reflux for 5 hrs
3. filtrationThe resulting precipitate was filtered
4. washwashed with water and diethyl ether