反应详情

A suspension of 2-{3-[4-(2-methoxyphenyl)piperazino]propanoyl}-N-phenyl-1-hydrazine carboxamide D5 (1.00 g, 2.50 mmol) in 2M NaOH aqueous solution (10 mL) was heated at reflux for 5 hrs. The pH of the solution was adjusted to 8 by the sequential addition of HCl 28% and NaOH, and the resulting white precipitate was filtered, washed with water and diethyl ether to afford 0.80 g (84%) 5-{2-[4-(2-methoxyphenyl)piperazino]ethyl}-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one E2.

1. temperaturewas heated
2. temperatureat reflux for 5 hrs
3. filtrationthe resulting white precipitate was filtered
4. washwashed with water and diethyl ether