Hydrogen Bromide → HCID 59403478, compound

HRID 1514193Notes

Reaction equation

HRID 1514193 reaction equation
C[O:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[NH:8][CH2:9][CH2:10][O:11][C:5]=2[CH:4]=1.Br>>[OH:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[NH:8][CH2:9][CH2:10][O:11][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 598978565755-00-0

Product 1

HCID 59403478HCID 59403478, compoundYield 117%

Conditions

Temperature
110 °C

Procedure

A mixture of 8-(methyloxy)-3,4-dihydro-1,4-benzoxazepin-5(2H)-one (Preparation 25) (7.98 g, 41.3 mmol) and hydrobromic acid (100 ml, 1842 mmol) was stirred and heated at 110° C. for 7 hours. Then the reaction mixture was evaporated and azeotroped twice with 150 ml of ethanol to give the title compound (8.66 g) light brown solid which was used without purification. MS (ES) C9H9NO3 requires 179; found 180 [M+H]+.

Workup

  1. customThen the reaction mixture was evaporated
  2. customazeotroped twice with 150 ml of ethanol

Sources & evidence

ORD record
ord-8e86bd5396de46cf86608ab125613222
Source dataset
uspto-grants-2012_07
Patent number
US08222245B2

Reaction notes

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