Hydrochloric Acid → HCID 68467900, compound

Participants

Reaction Steps

1,1-Dimethylethyl-7-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (Preparation 44) (550 mg, 1.06 mmol) was dissolved in 4M HCl in dioxane (5 ml) and the solution stirred for 2 h. The title compound was filtered off as a white solid and dried in a vacuum oven (259 mg, 0.57 mmol). δH (d6DMSO, 400 MHz): 9.23 (2H, brs), 8.40 (1H, dd), 8.31 (1H, d), 7.96 (1H, d), 7.93 (1H, dd), 7.59 (1H, d), 7.44 (1H, d), 4.98 (1H, septet), 3.27-3.18 (8H, m), 1.36 (6H, d); MS (ES): C22H22F3N3O2 requires 417; found 418 [M+H]+.

Provenance & Evidence