Hydrochloric Acid → HCID 68467900, compound

HRID 1514271Notes

Reaction equation

HRID 1514271 reaction equation
CC([CH:5]1[C:11]2[CH:12]=[CH:13][C:14]([C:16]3[N:20]=[C:19]([C:21]4[CH:26]=[CH:25][C:24]([O:27][CH:28]([CH3:30])[CH3:29])=[C:23]([C:31]([F:34])([F:33])[F:32])[CH:22]=4)[O:18][N:17]=3)=[CH:15][C:10]=2[CH2:9][CH2:8][N:7](C([O-])=O)[CH2:6]1)(C)C.[ClH:38]>O1CCOCC1>[ClH:38].[CH3:30][CH:28]([O:27][C:24]1[CH:25]=[CH:26][C:21]([C:19]2[O:18][N:17]=[C:16]([C:14]3[CH:13]=[CH:12][C:11]4[CH2:5][CH2:6][NH:7][CH2:8][CH2:9][C:10]=4[CH:15]=3)[N:20]=2)=[CH:22][C:23]=1[C:31]([F:33])([F:34])[F:32])[CH3:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86643301HCID 86643301, compound

Product 1

HCID 68467900HCID 68467900, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1,1-Dimethylethyl-7-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (Preparation 44) (550 mg, 1.06 mmol) was dissolved in 4M HCl in dioxane (5 ml) and the solution stirred for 2 h. The title compound was filtered off as a white solid and dried in a vacuum oven (259 mg, 0.57 mmol). δH (d6DMSO, 400 MHz): 9.23 (2H, brs), 8.40 (1H, dd), 8.31 (1H, d), 7.96 (1H, d), 7.93 (1H, dd), 7.59 (1H, d), 7.44 (1H, d), 4.98 (1H, septet), 3.27-3.18 (8H, m), 1.36 (6H, d); MS (ES): C22H22F3N3O2 requires 417; found 418 [M+H]+.

Workup

  1. filtrationThe title compound was filtered off as a white solid
  2. customdried in a vacuum oven (259 mg, 0.57 mmol)

Sources & evidence

ORD record
ord-289674f12a0e49bb9caa96f4bbb77cff
Source dataset
uspto-grants-2012_07
Patent number
US08222245B2

Reaction notes

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