Hydrochloric Acid → HCID 68469721, compound

HRID 1514272Notes

Reaction equation

HRID 1514272 reaction equation
CC([CH:5]1[C:11]2[CH:12]=[CH:13][C:14]([C:16]3[N:20]=[C:19]([C:21]4[CH:26]=[CH:25][C:24]([C:27]5[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=5)=[C:23]([C:33]([F:36])([F:35])[F:34])[CH:22]=4)[O:18][N:17]=3)=[CH:15][C:10]=2[CH2:9][CH2:8][N:7](C([O-])=O)[CH2:6]1)(C)C.[ClH:40]>O1CCOCC1>[ClH:40].[F:36][C:33]([F:34])([F:35])[C:23]1[CH:22]=[C:21]([C:19]2[O:18][N:17]=[C:16]([C:14]3[CH:13]=[CH:12][C:11]4[CH2:5][CH2:6][NH:7][CH2:8][CH2:9][C:10]=4[CH:15]=3)[N:20]=2)[CH:26]=[CH:25][C:24]=1[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86643302HCID 86643302, compound

Product 1

HCID 68469721HCID 68469721, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1,1-Dimethylethyl-7-{5-[2-(trifluoromethyl)-4-biphenylyl]-1,2,4-oxadiazol-3-yl}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (Preparation 45) (440 mg, 0.82 mmol) was dissolved in 4M HCl in dioxane (3 ml) and the solution stirred for 2 h. The title compound was filtered off as a white solid (376 mg, 0.82 mmol). δH (d6DMSO, 400 MHz): 9.27 (2H, brs), 8.53 (1H, d), 8.51 (1H, dd), 8.01 (1H, d), 7.97 (1H, dd), 7.74 (1H, d), 7.54-7.50 (3H, m), 7.47 (1H, d), 7.43-7.39 (2H, m), 3.28-3.20 (8H, m). MS (ES): C25H20F3N3O requires 435; found 436 [M+H]+.

Sources & evidence

ORD record
ord-505f43b5098549c5acac66fcb427f369
Source dataset
uspto-grants-2012_07
Patent number
US08222245B2

Reaction notes

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