反应详情

4-Chloroaniline (10 g, 78.4 mmol) and formic acid were heated to reflux for 30 minutes. The reaction mixture was concentrated in vacuo. Water was added and basified with sodium carbonate and extracted with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtrated and evaporated to give N-(4-chloro-phenyl)-formamide (10.7 g, 88%).

1. temperatureto reflux for 30 minutes
2. concentrationThe reaction mixture was concentrated in vacuo
3. additionWater was added
4. extractionextracted with ethyl acetate
5. dry with materialThe combined organic phases were dried over magnesium sulphate
6. filtrationfiltrated
7. customevaporated