Chloroform → 4-(4-cyclopropyl-1-methylpyrazol-5-yl)-N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]thiophene-2-carboxamide

HRID 151436Notes

Reaction equation

HRID 151436 reaction equation
[CH:1]1([c:4]2[cH:5][n:6][n:7]([CH3:17])[c:8]2-[c:9]2[cH:10][c:11]([C:14](=[O:15])[OH:16])[s:12][cH:13]2)[CH2:2][CH2:3]1.[CH:43]([N:44]([CH2:45][CH3:46])[CH:47]([CH3:48])[CH3:49])([CH3:50])[CH3:51].[CH:52]([Cl:53])([Cl:54])[Cl:55].[NH2:18][CH:19]([CH2:20][N:21]1[C:22](=[O:31])[c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2[C:29]1=[O:30])[CH2:32][c:33]1[c:34]([C:39]([F:40])([F:41])[F:42])[cH:35][cH:36][cH:37][cH:38]1>>[CH:1]1([c:4]2[cH:5][n:6][n:7]([CH3:17])[c:8]2-[c:9]2[cH:10][c:11]([C:14](=[O:16])[NH:18][CH:19]([CH2:20][N:21]3[C:22](=[O:31])[c:23]4[cH:24][cH:25][cH:26][cH:27][c:28]4[C:29]3=[O:30])[CH2:32][c:33]3[c:34]([C:39]([F:40])([F:41])[F:42])[cH:35][cH:36][cH:37][cH:38]3)[s:12][cH:13]2)[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 6212ChloroformHCID 81531DiisopropylethylamineHCID 578266304-(4-cyclopropyl-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylic AcidHCID 1785107622-[2-amino-3-[2-(trifluoromethyl)phenyl]propyl]isoindole-1,3-dione

Product 1

HCID 765765874-(4-cyclopropyl-1-methylpyrazol-5-yl)-N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]thiophene-2-carboxamide

Sources & evidence

ORD record
ord-df637046b4424ce2ac322f69f98481d0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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