Dimethylcarbamoyl Chloride → (R)-N,N,3-trimethyl-4-(1-phenylpyrido[4,3-d]pyridazin-4-yl)piperazine-1-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Dimethylcarbamoyl Chloride	HCID 6598	—
Reactant	Triethylamine	HCID 8471	—
Reactant	(R)-4-(2-methylpiperazin-1-yl)-1-phenylpyrido[3,4-d]pyridazine	HCID 57657605	—
Product	(R)-N,N,3-trimethyl-4-(1-phenylpyrido[4,3-d]pyridazin-4-yl)piperazine-1-carboxamide	HCID 25226952	—

Reaction Steps

Using methods described in Example 18, and starting with (R)-4-(2-methylpiperazin-1-yl)-1-phenylpyrido[4,3-d]pyridazine 16 (125 mg, 409 μmol), triethylamine (86 μl, 614 μmol) and N,N-dimethylcarbamoyl chloride (41 μl, 450 μmol) afforded (R)—N,N,3-trimethyl-4-(1-phenylpyrido[4,3-d]pyridazin-4-yl)piperazine-1-carboxamide 39. MS 376.2 (calc'd) 377.2 (M+H, found).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08222251B2
Source dataset	uspto-grants-2012_07
ORD ID	ord-5fee955763be4fe9ac9d1b930bae91fd
Source note	uspto-grants-2012_07