反应详情

Using methods described in Example 18, and starting with (R)-4-(2-methylpiperazin-1-yl)-1-phenylpyrido[4,3-d]pyridazine 16 (125 mg, 409 μmol), triethylamine (86 μl, 614 μmol) and N,N-dimethylcarbamoyl chloride (41 μl, 450 μmol) afforded (R)—N,N,3-trimethyl-4-(1-phenylpyrido[4,3-d]pyridazin-4-yl)piperazine-1-carboxamide 39. MS 376.2 (calc'd) 377.2 (M+H, found).