Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus oxychloride → 4-Chloro-5-methyl-2-(methylsulfanyl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 5-Methyl-2-(methylthio)pyrimidin-4(3H)-one | HCID 240575 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-Chloro-5-methyl-2-(methylsulfanyl)pyrimidine | HCID 23562708 | 89% |
반응 단계
A mixture of 5-methyl-2-methylsulfanyl-3H-pyrimidin-4-one (6.86 g, 44 mmol) and POCl3 (14 ml) in dioxane (60 ml) was refluxed for 2 hours. The solvent was removed under vacuum and the residue was quenched with ice and extracted with diethylether. The organic phase was dried (Na2SO4) and evaporated to give 6.8 g of the title compound as oil that was used in the next step without further purification. (89% yield)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08222266B2 |
| 출처 데이터셋 | uspto-grants-2012_07 |
| ORD ID | ord-3d097722860d4ba3a29d4cf7f1820570 |
| 출처 메모 | uspto-grants-2012_07 |