反应详情

A mixture of 5-methyl-2-methylsulfanyl-3H-pyrimidin-4-one (6.86 g, 44 mmol) and POCl3 (14 ml) in dioxane (60 ml) was refluxed for 2 hours. The solvent was removed under vacuum and the residue was quenched with ice and extracted with diethylether. The organic phase was dried (Na2SO4) and evaporated to give 6.8 g of the title compound as oil that was used in the next step without further purification. (89% yield)

1. temperaturewas refluxed for 2 hours
2. customThe solvent was removed under vacuum
3. customthe residue was quenched with ice
4. extractionextracted with diethylether
5. dry with materialThe organic phase was dried (Na2SO4)
6. customevaporated