反应详情

A solution of 4-(6-methyl-pyridin-2-yl)-2-methylsulfanyl-pyrimidine (785 mg, 3.61 mmol) in MeOH (25 ml) was cooled at 0° C. and then an aqueous solution of oxone (6.67 g, 10.85 mmol in 25 ml of water) was slowly added. After stirring 3 hours at room temperature, the mixture was basified with 5% NaHCO3 and the product was extracted with ethyl acetate. The organic phase was dried (Na2SO4) and evaporated to give 625 mg of the title compound that was used in the next step without further purification (70% yield).

1. extractionthe product was extracted with ethyl acetate
2. dry with materialThe organic phase was dried (Na2SO4)
3. customevaporated