Sodium Bicarbonate → HCID 59242795, compound

HRID 1514416Notes

Reaction equation

HRID 1514416 reaction equation
[F:1][C:2]1([F:19])[O:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11]3[CH:16]=[CH:15][N:14]=[C:13](SC)[N:12]=3)[C:4]=2[O:3]1.O[O:21][S:22]([O-:24])=O.[K+].[C:26]([O-])(O)=O.[Na+]>CO>[F:19][C:2]1([F:1])[O:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11]3[CH:16]=[CH:15][N:14]=[C:13]([S:22]([CH3:26])(=[O:24])=[O:21])[N:12]=3)[C:4]=2[O:3]1

Participants

5

Reactant 3

HCID 516892Sodium BicarbonateHCID 23707502Potassium hydroxy sulfiteHCID 59242791HCID 59242791, compound

Product 1

HCID 59242795HCID 59242795, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2-methylsulfanyl-pyrimidine (326 mg, 1.15 mmol) in MeOH (8 ml) was cooled at 0° C. and then an aqueous solution of oxone (2.31 g, 3.76 mmol in 8 ml of water) was slowly added. After stirring 2 hours at room temperature, the mixture was basified with 5% NaHCO3 and the product was extracted with ethyl acetate. The organic phase was dried (Na2SO4) and evaporated to give 364 mg of the title compound that was used in the next step without further purification (quantitative yield).

Workup

  1. extractionthe product was extracted with ethyl acetate
  2. dry with materialThe organic phase was dried (Na2SO4)
  3. customevaporated

Sources & evidence

ORD record
ord-d15dd9f919634730b4c82d5cecc18307
Source dataset
uspto-grants-2012_07
Patent number
US08222266B2

Reaction notes

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