Sodium Bicarbonate → HCID 59242804, compound

HRID 1514420Notes

Reaction equation

HRID 1514420 reaction equation
[CH3:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]=[C:10](SC)[N:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.O[O:17][S:18]([O-:20])=O.[K+].[C:22]([O-])(O)=O.[Na+]>CO>[CH3:22][S:18]([C:10]1[N:9]=[C:8]([C:7]2[C:2]([CH3:1])=[N:3][CH:4]=[CH:5][CH:6]=2)[CH:13]=[CH:12][N:11]=1)(=[O:20])=[O:17]

Participants

5

Reactant 3

HCID 516892Sodium BicarbonateHCID 23707502Potassium hydroxy sulfiteHCID 59242778HCID 59242778, compound

Product 1

HCID 59242804HCID 59242804, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-(2-methyl-pyridin-3-yl)-2-methylsulfanyl-pyrimidine (530 mg, 2.44 mmol) in MeOH (18 ml) was cooled at 0° C. and then an aqueous solution of oxone (4.51 g, 7.32 mmol in 18 ml of water) was slowly added. After stirring 1.5 hours at room temperature, the mixture was basified with 5% NaHCO3 and the product was extracted with ethyl acetate. The organic phase was dried (Na2SO4) and evaporated to give 500 mg of the title compound that was used in the next step without further purification (80% yield).

Workup

  1. extractionthe product was extracted with ethyl acetate
  2. dry with materialThe organic phase was dried (Na2SO4)
  3. customevaporated

Sources & evidence

ORD record
ord-c6065a1554614ab383d49b5a56652f5b
Source dataset
uspto-grants-2012_07
Patent number
US08222266B2

Reaction notes

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