Sodium Bicarbonate → HCID 59242799, compound

HRID 1514424Notes

Reaction equation

HRID 1514424 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10](SC)[N:9]=2)[CH:5]=[CH:4][N:3]=1.O[O:17][S:18]([O-:20])=O.[K+].[C:22]([O-])(O)=O.[Na+]>CO>[CH3:22][S:18]([C:10]1[N:9]=[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=2)[CH:13]=[CH:12][N:11]=1)(=[O:20])=[O:17]

Participants

5

Reactant 3

HCID 516892Sodium BicarbonateHCID 23707502Potassium hydroxy sulfiteHCID 59242775HCID 59242775, compound

Product 1

HCID 59242799HCID 59242799, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-(2-methyl-pyridin-4-yl)-2-methylsulfanyl-pyrimidine (990 mg, 4.56 mmol) in MeOH (35 ml) was cooled at 0° C. and then an aqueous solution of oxone (8.41 g, 13.85 mmol in 35 ml of water) was slowly added. After stirring 3.5 hours at room temperature, the mixture was basified with solid NaHCO3 and the product was extracted with ethyl acetate. The organic phase was dried (Na2SO4) and evaporated to give 720 mg of the title compound that was used in the next step without further purification (65% yield).

Workup

  1. extractionthe product was extracted with ethyl acetate
  2. dry with materialThe organic phase was dried (Na2SO4)
  3. customevaporated

Sources & evidence

ORD record
ord-3d3ce77e0f474069a4334cd67cd3ee40
Source dataset
uspto-grants-2012_07
Patent number
US08222266B2

Reaction notes

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