1,4-Dioxane → HCID 178434747, compound

HRID 1514429Notes

Reaction equation

HRID 1514429 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][N:10]=[C:9](S(C)(=O)=O)[N:8]=2)=[C:5]([CH3:17])[O:4][N:3]=1.[O:18]1CCOCC1>>[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][NH:10][C:9](=[O:18])[N:8]=2)=[C:5]([CH3:17])[O:4][N:3]=1

Participants

3

Reactant 2

HCID 312751,4-DioxaneHCID 59242800HCID 59242800, compound

Product 1

HCID 178434747HCID 178434747, compound

Procedure

4-(3,5-dimethyl-isoxazol-4-yl)-2-methanesulfonyl-pyrimidine (666 mg, 2.63 mmol) was dissolved in dioxane (20 ml) and then 2N NaOHaq (13.2 ml, 26.3 mmol) was added. After stirring at room temperature for 30 minutes, the solution was acidified with 37% HClaq. The mixture was evaporated and the residue was purified by flash chromatography with DCM-MeOH (9-1) to give the title compound. (quantitative yield).

Workup

  1. addition2N NaOHaq (13.2 ml, 26.3 mmol) was added
  2. customThe mixture was evaporated
  3. customthe residue was purified by flash chromatography with DCM-MeOH (9-1)

Sources & evidence

ORD record
ord-60a1448f9dae4b9a8845d5fa2370e2f2
Source dataset
uspto-grants-2012_07
Patent number
US08222266B2

Reaction notes

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