1,4-Dioxane → HCID 178434747, compound

Participants

Reaction Steps

4-(3,5-dimethyl-isoxazol-4-yl)-2-methanesulfonyl-pyrimidine (666 mg, 2.63 mmol) was dissolved in dioxane (20 ml) and then 2N NaOHaq (13.2 ml, 26.3 mmol) was added. After stirring at room temperature for 30 minutes, the solution was acidified with 37% HClaq. The mixture was evaporated and the residue was purified by flash chromatography with DCM-MeOH (9-1) to give the title compound. (quantitative yield).

Provenance & Evidence