Sodium Bicarbonate → HCID 58742216, compound

HRID 1514441Notes

Reaction equation

HRID 1514441 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][N:11]=[C:10](SC)[N:9]=2)=[C:5]([CH3:7])[N:6]=1.O[O:17][S:18]([O-:20])=O.[K+].[C:22]([O-])(O)=O.[Na+]>CO>[CH3:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([S:18]([CH3:22])(=[O:20])=[O:17])[N:9]=2)=[C:5]([CH3:7])[N:6]=1

Participants

5

Reactant 3

HCID 516892Sodium BicarbonateHCID 23707502Potassium hydroxy sulfiteHCID 587422264-(2,4-Dimethyl-thiazol-5-yl)-2-methylsulfanyl-pyrimidine

Product 1

HCID 58742216HCID 58742216, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-(2,4-dimethyl-thiazol-5-yl)-2-methylsulfanyl-pyrimidine (342 mg, 1.44 mmol) in MeOH (12 ml) was cooled at 0° C., then an aqueous solution of oxone (2.65 g, 4.32 mmol in 12 ml of water) was slowly added. After stirring 2 hours at room temperature, the mixture was basified with 5% NaHCO3 and the product was extracted with ethyl acetate. The organic phase was dried (Na2SO4) and evaporated to give 288 mg of the title compound that was used in the next step without further purification (75% yield).

Workup

  1. extractionthe product was extracted with ethyl acetate
  2. dry with materialThe organic phase was dried (Na2SO4)
  3. customevaporated

Sources & evidence

ORD record
ord-c64d34ced7b444a792caf48cbc990fa2
Source dataset
uspto-grants-2012_07
Patent number
US08222266B2

Reaction notes

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