Hydrochloric Acid → HCID 68699413, compound

HRID 1514449Notes

Reaction equation

HRID 1514449 reaction equation
[CH3:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][C@H:22]4[C@:20]([C:24]5[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=5)([CH2:21]4)[CH2:19]3)[C:10](=[O:34])[N:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:35].O1CCOCC1>>[ClH:35].[CH3:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][C@H:22]4[C@:20]([C:24]5[CH:25]=[CH:26][C:27]([C:30]([F:31])([F:32])[F:33])=[CH:28][CH:29]=5)([CH2:21]4)[CH2:19]3)[C:10](=[O:34])[N:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 24752777HCID 24752777, compound

Product 1

HCID 68699413HCID 68699413, compound

Procedure

4-(2-Methyl-pyridin-3-yl)-1-{4-[(1S,5R)-1-(4-trifluoromethyl-phenyl)-3-aza-bicyclo[3.1.0]hex-3-yl]-butyl}-1H-pyrimidin-2-one was treated with 4N HCl in dioxane (1 eq), to give the title compound.

Sources & evidence

ORD record
ord-c9e7ed5c174d46ab9d5dbde4946263b6
Source dataset
uspto-grants-2012_07
Patent number
US08222266B2

Reaction notes

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