2,2,2-Trifluoroethylamine hydrochloride → HCID 46929237, compound

HRID 1514737Notes

Reaction equation

HRID 1514737 reaction equation
[CH2:1]([C:5]1[C:9]([CH2:10][O:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([OH:18])=O)=[CH:14][N:13]=2)=[C:8]([CH2:21][OH:22])[O:7][N:6]=1)[CH2:2][CH2:3][CH3:4].Cl.[F:24][C:25]([F:29])([F:28])[CH2:26][NH2:27]>>[CH2:1]([C:5]1[C:9]([CH2:10][O:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([NH:27][CH2:26][C:25]([F:29])([F:28])[F:24])=[O:18])=[CH:14][N:13]=2)=[C:8]([CH2:21][OH:22])[O:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 97722,2,2-Trifluoroethylamine hydrochlorideHCID 66718228HCID 66718228, compound

Product 1

HCID 46929237HCID 46929237, compoundYield 18%

Procedure

As described in example 53g, 6-[3-butyl-5-hydroxymethyl-isoxazol-4-ylmethoxy]-nicotinic acid (49 mg, 0.16 mmol) was converted, using 2,2,2-trifluoroethylamine hydrochloride instead of cyclobutylamine, to the title compound (11 mg, 18%) which was obtained as a colorless oil. MS: m/e=388.2 [M+H]+.

Sources & evidence

ORD record
ord-52712092030a46548546eee6b70136e0
Source dataset
uspto-grants-2012_07
Patent number
US08222246B2

Reaction notes

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