HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethylamine hydrochloride → HCID 46929237, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethylamine hydrochloride | HCID 9772 | — |
| Reactant | HCID 66718228 | HCID 66718228 | — |
| Product | HCID 46929237 | HCID 46929237 | 18% |
Reaction Steps
As described in example 53g, 6-[3-butyl-5-hydroxymethyl-isoxazol-4-ylmethoxy]-nicotinic acid (49 mg, 0.16 mmol) was converted, using 2,2,2-trifluoroethylamine hydrochloride instead of cyclobutylamine, to the title compound (11 mg, 18%) which was obtained as a colorless oil. MS: m/e=388.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222246B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-52712092030a46548546eee6b70136e0 |
| Source note | uspto-grants-2012_07 |