Morpholine → HCID 46929240, compound

HRID 1514744Notes

Reaction equation

HRID 1514744 reaction equation
[OH:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[C:4]=1[CH2:14][O:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([OH:22])=O)=[CH:18][N:17]=1.[NH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>>[OH:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[C:4]=1[CH2:14][O:15][C:16]1[N:17]=[CH:18][C:19]([C:20]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)=[O:22])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 66718204HCID 66718204, compound

Product 1

HCID 46929240HCID 46929240, compoundYield 69%

Procedure

As described in example 43h, 6-(5-hydroxymethyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid (881 mg, 2.7 mmol) was converted, using morpholine instead of thiomorpholine 1,1-dioxide, to the title compound (738 mg, 69%) which was obtained as a white foam. MS: m/e=397.3 [M+H]+.

Sources & evidence

ORD record
ord-9a51208dbe174e5dbfc9dd35ba062b4a
Source dataset
uspto-grants-2012_07
Patent number
US08222246B2

Reaction notes

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