Hydrochloric Acid → HCID 66966524, compound

HRID 1514900Notes

Reaction equation

HRID 1514900 reaction equation
C[O:2][C:3]([C:5]1[CH:24]=[CH:23][C:8]2[N:9]=[C:10]([C:12]3[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:22])[NH:11][C:7]=2[CH:6]=1)=[O:4].[OH-].[Na+].Cl>CO>[Cl:22][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]([C:18]([F:20])([F:21])[F:19])[C:12]=1[C:10]1[NH:11][C:7]2[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:24]=[CH:23][C:8]=2[N:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66965685HCID 66965685, compound

Product 1

HCID 66966524HCID 66966524, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of 2-(2-chloro-6-trifluoromethylphenyl)-3H-benzoimidazole-5-carboxylic acid methyl ester (430 mg, 1.2 mmol) in MeOH (5 mL) was added 1N NaOH (5 mL). The solution was stirred at ambient temperature overnight and carefully acidified to pH 3 with 1N HCl. The resulting suspension was filtered and washed with water. The pale yellow solid was dried under reduced pressure give 2-(2-chloro-6-trifluoromethylphenyl)-3H-benzoimidazole-5-carboxylic acid.

Workup

  1. filtrationThe resulting suspension was filtered
  2. washwashed with water
  3. customThe pale yellow solid was dried under reduced pressure

Sources & evidence

ORD record
ord-f67c3e57f3914088a042b888103ad405
Source dataset
uspto-grants-2012_07
Patent number
US08222248B2

Reaction notes

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