反应详情

To a stirred solution of 4-amino-2,3-difluoro-5-nitrobenzoic acid methyl ester (500 mg, 2.2 mmol) in EtOH (20 ml) was added PtO2 (50 mg, 10% w). The suspension was hydrogenated with a H2 balloon overnight. The catalyst was filtered through Celite and washed with EtOH The solvent was removed under reduced pressure to give 4,5-diamino-2,3-difluorobenzoic acid methyl ester as a light yellow solid.

1. customwas hydrogenated with a H2 balloon overnight
2. filtrationThe catalyst was filtered through Celite
3. washwashed with EtOH The solvent
4. customwas removed under reduced pressure