反应详情

To a stirred solution of 2-(2,6-dichlorophenyl)-6,7-difluoro-3H-benzoimidazole-5-carboxylic acid methyl ester (700 mg, 1.97 mmol) in MeOH (15 mL) was added 1N NaOH (10 mL). The solution was stirred at ambient temperature overnight and carefully acidified to pH 3 with 1N HCl. The resulting suspension was filtered and washed with water. The pale yellow solid was dried under reduced pressure to give 2-(2,6-dichlorophenyl)-6,7-difluoro-3H-benzoimidazole-5-carboxylic acid.

1. filtrationThe resulting suspension was filtered
2. washwashed with water
3. customThe pale yellow solid was dried under reduced pressure