HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(2,6-dichlorophenyl)-6,7-difluoro-3H-benzoimidazole-5-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 66966139 | HCID 66966139 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 2-(2,6-dichlorophenyl)-6,7-difluoro-3H-benzoimidazole-5-carbonyl chloride | HCID 86651264 | — |
Reaction Steps
To a stirred suspension of 2-(2,6-dichlorophenyl)-6,7-difluoro-3H-benzoimidazole-5-carboxylic acid (570 mg, 1.67 mmol) in SOCl2 (10 mL) was added 3 drops of DMF. The suspension was stirred at ambient temperature overnight. The solid was filtered and washed with CH2Cl2 and was dried under reduced pressure to give 2-(2,6-dichlorophenyl)-6,7-difluoro-3H-benzoimidazole-5-carbonyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222248B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-1dfc5cabdb43473ba1a77e6fc96a3979 |
| Source note | uspto-grants-2012_07 |