反应详情

To a stirred solution of 2,4,6-trichlorobenzoic acid (451 mg, 2.0 mmol) in THF (15 mL) was added BH3 (3 mL of a 1M solution in THF). After the addition, the solution was refluxed overnight. The reaction was quenched with water and the aqueous layer was extracted with EtOAc. The organic layer was washed with water, brine, dried with MgSO4, and filtered. The solvent was removed under reduced pressure to give (2,4,6-trichlorophenyl)-methanol as a white solid.

1. additionAfter the addition
2. temperaturethe solution was refluxed overnight
3. customThe reaction was quenched with water
4. extractionthe aqueous layer was extracted with EtOAc
5. washThe organic layer was washed with water, brine
6. dry with materialdried with MgSO4
7. filtrationfiltered
8. customThe solvent was removed under reduced pressure