反应详情

温度

60 °C

To a suspension of 2-(2,6-dichlorophenyl)-1-methyl-1H-benzoimidazole-5-carboxylic acid ethyl ester (400 mg) in EtOH (8 mL) was added 1.0 N NaOH (2.0 mL) and the mixture was stirred at 60° C. for 90 min. The ethanol was removed under reduced pressure and water (10 mL) was added. Any insoluble material was filtered and 2.0N HCl (2.0 mL) was added to the filtrate. The resulting precipitate was filtered, washed with water and dried under reduced pressure to give 2-(2,6-dichlorophenyl)-1-methyl-1H-benzoimidazole-5-carboxylic acid as a white solid, mp>250° C.; MS (m/z) 321 (M+1).

1. customThe ethanol was removed under reduced pressure and water (10 mL)
2. additionwas added
3. filtrationAny insoluble material was filtered
4. addition2.0N HCl (2.0 mL) was added to the filtrate
5. filtrationThe resulting precipitate was filtered
6. washwashed with water
7. customdried under reduced pressure