HCID 86638179, compound → HCID 86638180, compound

HRID 1514985Notes

Reaction equation

HRID 1514985 reaction equation
[C:1]([O:5][C:6](=[O:19])[CH:7]=[CH:8][C:9]1[CH:14]=[C:13]([CH3:15])[C:12]([CH:16]=[O:17])=[C:11]([CH3:18])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]>C(Cl)Cl.[Pd]>[C:1]([O:5][C:6](=[O:19])[CH2:7][CH2:8][C:9]1[CH:14]=[C:13]([CH3:15])[C:12]([CH:16]=[O:17])=[C:11]([CH3:18])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 86638179HCID 86638179, compound

Product 1

HCID 86638180HCID 86638180, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of 3-(4-formyl-3,5-dimethylphenyl)-acrylic acid tert-butyl ester (210 mg) in CH2Cl2 (8 mL) was hydrogenated at 1 atm over 10% Pd/C (21 mg) for 4 h. The catalyst was filtered and the filtrate concentrated to give 3-(4-formyl-3,5-dimethylphenyl)-propionic acid tert-butyl ester as a yellow solid. MS (ESI)m/z 286 (M+H).

Workup

  1. filtrationThe catalyst was filtered
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-60b16fee257642adbde92ade0e8a4e1e
Source dataset
uspto-grants-2012_07
Patent number
US08222248B2

Reaction notes

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