反应详情

To a stirred solution of 4-(tert-butyldimethyl-silanyloxy)-2,6-dimethylbenzaldehyde (2.4 g, 9 mmol) in THF (10 mL) was added TBAF (10 mL of a 1.0 M solution in THF). After an hour at ambient temperature, the reaction mixture was quenched with water and the aqueous layer was extracted with EtOAc. The organic layer was washed with water, brine, dried with MgSO4 and filtered. The solvent was removed under reduced pressure to give 4-hydroxy-2,6-dimethylbenzaldehyde as a yellow oil.

1. waitAfter an hour at ambient temperature
2. customthe reaction mixture was quenched with water
3. extractionthe aqueous layer was extracted with EtOAc
4. washThe organic layer was washed with water, brine
5. dry with materialdried with MgSO4
6. filtrationfiltered
7. customThe solvent was removed under reduced pressure