HCID 46671823、化合物 → 3,4-diamino-N-quinolin-2-yl-benzamide

HRID 1515011ノート

反応式

HRID 1515011 の反応式
[NH2:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=2)=[O:7])=[CH:4][C:3]=1[N+:21]([O-])=O>CCO.O=[Pt]=O>[NH2:21][C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][C:2]=1[NH2:1])[C:6]([NH:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1)=[O:7]

参加物

4

反応物 1

HCID 46671823HCID 46671823、化合物

生成物 1

HCID 669657403,4-diamino-N-quinolin-2-yl-benzamide

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

A suspension of the above 4-amino-3-nitro-N-quinolin-2-yl-benzamide (5 g, 16.2 mmol) in EtOH (50 mL) was hydrogenated at one atm over PtO2 (250 mg) for 4 h (the suspension will become a clear when the reaction is complete). The catalyst was filtered through Celite and washed with EtOH. The solvent was removed under reduced pressure to give 3,4-diamino-N-quinolin-2-yl-benzamide as a red solid.

後処理

  1. filtrationThe catalyst was filtered through Celite
  2. washwashed with EtOH
  3. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-62f669970edf43c1abf4f1dfcf753637
出典データセット
uspto-grants-2012_07
特許番号
US08222248B2

反応ノート

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