HCID 66965236, compound → HCID 66966238, compound

HRID 1515015Notes

Reaction equation

HRID 1515015 reaction equation
[NH2:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11][N:10]=2)=[O:7])=[CH:4][C:3]=1[N+:21]([O-])=O>CO.[Pt]=O>[NH2:21][C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][C:2]=1[NH2:1])[C:6]([NH:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][N:10]=1)=[O:7]

Participants

4

Reactant 1

HCID 66965236HCID 66965236, compound

Product 1

HCID 66966238HCID 66966238, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

A suspension of give 4-amino-N-isoquinolin-1-yl-3-nitrobenzamide and platinum oxide (330 mg) in MeOH (100 mL) was hydrogenated at 40 psi for 18 h. The catalyst was filtered from the solution through Celite and the filtrate evaporated to give 3,4-diamino-N-isoquinolin-1-yl-benzamide as a thick oil. MS (ESI) m/z 279.1 (M+H).

Workup

  1. filtrationThe catalyst was filtered from the solution through Celite
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-bfbc9bf6628a4264845f6132dc0de96d
Source dataset
uspto-grants-2012_07
Patent number
US08222248B2

Reaction notes

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