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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1515031Generated: October 27, 2026

4-amino-N-(4-tert-butylphenyl)-3-nitrobenzamide → 3,4-diamino-N-(4-tert-butylphenyl)-benzamide

https://huagongshe.com/reaction/1515031

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-amino-N-(4-tert-butylphenyl)-3-nitrobenzamideHCID 8779856—
CatalystPlatinumHCID 23939—
SolventEthanol ethylacetateHCID 21584252—
Product3,4-diamino-N-(4-tert-butylphenyl)-benzamideHCID 66966111—

Reaction Steps

A mixture of 4-amino-N-(4-tert-butylphenyl)-3-nitrobenzamide from the previous step and 100 mg of 5% platinum on carbon in 50 mL of 1:1 ethyl acetate/ethanol was reduced under a hydrogen balloon. The reaction was filtered through Celite to remove catalyst and the solvent was removed under reduced pressure to afford 3,4-diamino-N-(4-tert-butylphenyl)-benzamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08222248B2
Source datasetuspto-grants-2012_07
ORD IDord-fb2cdefe1a4e4388b259a9679c5c2a4f
Source noteuspto-grants-2012_07