3,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamide → HCID 178424983, compound

HRID 1515043Notes

Reaction equation

HRID 1515043 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[NH2:21])[C:5]([NH:7][C:8]1[CH:9]=[N:10][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:13]=1)=[O:6].C[O:23][C:24](=[O:39])[C:25]([CH3:38])([CH3:37])[CH2:26][C:27]1[CH:32]=[C:31]([CH3:33])[C:30]([CH:34]=O)=[C:29]([CH3:36])[CH:28]=1>>[CH3:36][C:29]1[CH:28]=[C:27]([CH2:26][C:25]([CH3:38])([CH3:37])[C:24]([OH:39])=[O:23])[CH:32]=[C:31]([CH3:33])[C:30]=1[C:34]1[NH:21][C:20]2[CH:19]=[CH:18][C:4]([C:5](=[O:6])[NH:7][C:8]3[CH:9]=[N:10][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:12][CH:13]=3)=[CH:3][C:2]=2[N:1]=1

Participants

3

Reactant 2

HCID 669656813,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamideHCID 86632822Methyl 3-(4-formyl-3,5-dimethylphenyl)-2,2-dimethylpropanoate

Product 1

HCID 178424983HCID 178424983, compound

Procedure

The title compound was prepared from 3,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamide (from Example 6-36) and 3-(4-formyl-3,5-dimethylphenyl)-2,2-dimethylpropionic acid methyl ester analogous to Example 6-29. 1N NMR (400 MHz, MeOD): δ 9.20 (s, 1H), 8.68 (d, 1H), 8.43 (s, 1H), 8.10 (d, 1H), 7.98 (d, 1H), 7.85 (d, 1H), 7.19 (s, 2H), 3.00 (s, 2H), 2.27 (s, 6H), 1.29 (s, 6H). MS (m/z) 511.2 (M+1); Retention time: 1.20 min (Method 10).

Sources & evidence

ORD record
ord-8c498e45672e436b92c00594e65af5a4
Source dataset
uspto-grants-2012_07
Patent number
US08222248B2

Reaction notes

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