3,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamide → HCID 66966087, 화합물

HRID 1515053노트

반응식

HRID 1515053 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[NH2:21])[C:5]([NH:7][C:8]1[CH:9]=[N:10][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:13]=1)=[O:6].C([O:24][P:25]([CH2:30]/[CH:31]=[CH:32]/[C:33]1[CH:38]=[C:37]([CH3:39])[C:36]([CH:40]=O)=[C:35]([CH3:42])[CH:34]=1)(=[O:29])[O:26]CC)C>>[CH3:42][C:35]1[CH:34]=[C:33]([CH2:32][CH2:31][CH2:30][P:25](=[O:24])([OH:29])[OH:26])[CH:38]=[C:37]([CH3:39])[C:36]=1[C:40]1[NH:1][C:2]2[CH:3]=[C:4]([C:5](=[O:6])[NH:7][C:8]3[CH:9]=[N:10][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:12][CH:13]=3)[CH:18]=[CH:19][C:20]=2[N:21]=1

참가 물질

3

반응물 2

HCID 669656813,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamideHCID 86632823[(E)-3-(4-formyl-3,5-dimethylphenyl)-allyl]-phosphonic acid diethyl ester

생성물 1

HCID 66966087HCID 66966087, 화합물

실험 절차

The title compound was prepared from 3,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamide and [(E)-3-(4-formyl-3,5-dimethylphenyl)-allyl]-phosphonic acid diethyl ester analogous to Example 6-32. 1H NMR (Methanol-d4, 400 MHz): δ 9.09 (d, 1H), 8.57 (dd, 1H), 8.34 (dd, 1H), 8.00 (dd, 1H), 7.87 (d, 1H), 7.76 (dd, 1H), 7.09 (s, 2H), 2.76 (t, 2H), 2.16 (s, 6H), 2.00 (m, 2H), 1.71 (m, 2H). MS (m/z) 533.1 (M+1); Retention time: 1.13 min (Method 10).

출처 및 근거

ORD 기록
ord-6849a0dd1d54483fa3a9f8c502d95c16
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08222248B2

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