3,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamide → HCID 66965764, compound

HRID 1515055Notes

Reaction equation

HRID 1515055 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[NH2:21])[C:5]([NH:7][C:8]1[CH:9]=[N:10][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:13]=1)=[O:6].C([O:26][C:27](=[O:40])[CH2:28][CH2:29][C:30]1[CH:35]=[C:34]([Cl:36])[C:33]([CH:37]=O)=[C:32]([Cl:39])[CH:31]=1)(C)(C)C>>[Cl:36][C:34]1[CH:35]=[C:30]([CH2:29][CH2:28][C:27]([OH:40])=[O:26])[CH:31]=[C:32]([Cl:39])[C:33]=1[C:37]1[NH:1][C:2]2[CH:3]=[C:4]([C:5](=[O:6])[NH:7][C:8]3[CH:9]=[N:10][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:12][CH:13]=3)[CH:18]=[CH:19][C:20]=2[N:21]=1

Participants

3

Reactant 2

HCID 669656813,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamideHCID 866328253-(3,5-Dichloro-4-formylphenyl)-propionic acid tert-butyl ester

Product 1

HCID 66965764HCID 66965764, compound

Procedure

The title compound was prepared from 3,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamide (from Example 6-36) and 3-(3,5-dichloro-4-formylphenyl)-propionic acid tert butyl ester analogous to Example 6-25. 1H NMR (MeOD, 400 MHz): δ 9.07 (d, 1H), 8.54 (dd, 1H), 8.35 (s, 1H), 7.99 (dd, 1H), 7.84 (dd, 1H), 7.76 (d, 1H), 7.52 (s, 2H), 3.01 (t, 2H), 2.69 (t, 2H); MS (m/z) 523.01 (M+1), Retention time=1.06 min (Method 10).

Sources & evidence

ORD record
ord-ea000969455744a8a79abe4408ebbd05
Source dataset
uspto-grants-2012_07
Patent number
US08222248B2

Reaction notes

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